(So basically my characters, whether male or female, only ever sleep with females.)
If a game gives me the option to play as a female, but there's mainly f/m content and only one or two token f/f encounters, I don't bother.
The only exception so far has been Corruption of Champions, where I also had a save with a female MC that slept with males as well as females, because there's a lot of pregnancy content that's only available that way.
I definitely prefer to self insert so I like male protagonists but every so often I enjoy putting myself in the opposite sex's shoes. If the game is good though it doesn't really matter.
In traditional games, I tend to play female MC because I feel that they have better cosmetic options and overall look better imo. For sexual games, I play male (or futa) MC.
For sex games, male, I'm not that much into lesbian sex, and most games playing a woman will cater to that side. Non sex games, don't care, if it's a custom char, will go with male, otherwise, just need the game to be good.
for porn games, both have advantages. males have the equipement to fuck with, while female characters mean there's always a character I want to see naked involved. combining these is a big advantage of futas