Naturally. If you're hinting at masturbation, then I have to disappoint you - pixel sets don't excite me. In these games, as in any other, I am interested in: 1. good gameplay, 2. in the case of VN, a good, deeply researched plot with convincing, lively characters. As an example, I passed VN - Ren'Py - DAZ - Reclaiming the Lost [0.11] [Passion Portal] / without a single sex scene, which I do not regret - I enjoyed reading, and a good, interesting plot.
I've been using my steam deck to play some games and usually I bind most of the controls in my right hand side and it worked really well especially for RPGMaker games
i tend to notice that there is a bit of a break in most H games for the animations, be it getting defeated or events that you need to walk into (say talking with a character) so its not to big of a deal. now if its one of those games where you get grabbed and the enemy does a DOT to you as long as you dont get away even then its fine for me as long as the game gives easy access to the whole roster of hostiles through near by saves.
RPGs usually have defeat CGs that are just cutscenes and 1 hand is enough for those. I don't think I would have any problems with using 2 hands though if the gameplay is good and there's an option to rewatch a scene.